Pure R-Alpha Lipoic Acid (600mg)
Pure R-Alpha Lipoic Acid (600mg)
Pure R-Alpha Lipoic Acid (600mg)
Pure R-form to support daily nerve function. Formulated to the match the exact doses from clinical trials.
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“I started taking 600mg per day a month and a half ago, and in addition to increasing my insulin sensitivity to a point where I had to lower the sensitivity and basal settings on my pump, the pain in my hands and feet just… stopped after about three weeks. I sleep fine. It could recur, but I haven’t gone this long with this little pain in years.”
This product sold out 3 times last year. We encourage you to take advantage of the limited sale and buy now. PS: Only available here, don't buy fakes on Amazon/eBay.
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Clinically Proven Benefits
Clinically Proven Benefits
Backed by clinical research on R-Alpha Lipoic Acid
- Supports healthy nerve function in adults†
- Supports mitochondrial energy production†
- Helps maintain healthy blood sugar levels already within normal range†
- Provides antioxidant support for cellular health†
- Pure R-form with enhanced bioavailability for optimal absorption†
Benefits observed in clinical studies of R-Alpha Lipoic Acid when used consistently as part of a healthy lifestyle. Individual results vary.
Can I take this with my medication?
Can I take this with my medication?
Yes. R-alpha lipoic acid (R-ALA) can often be taken alongside diabetes medications, but it should be done with caution because the combination may lower blood glucose more than expected.
Here's what the evidence suggests:
Generally compatible with:
- Metformin
- Insulin
- Sulfonylureas (e.g., glipizide, gliclazide, glyburide)
- SGLT2 inhibitors (e.g., empagliflozin, dapagliflozin)
- GLP-1 receptor agonists (e.g., semaglutide, tirzepatide)
- DPP-4 inhibitors (e.g., sitagliptin)
- Gabapentin
- Pregabalin (Lyrica)
- Duloxetine (Cymbalta)
- Amitriptyline
- Nortriptyline
- Venlafaxine
There are no well-established harmful drug interactions between R-ALA and these medications.
If unsure, please consult a physician.
How to Use
How to Use
Take three capsules daily with a glass of water, preferably with a meal. The time you take the supplement does not matter. Take it in the morning, afternoon, or night.
How long before I see results?
How long before I see results?
Most people notice subtle changes within 3-5 weeks of daily use. For full benefits, including improved nerve comfort and sleep quality, consistent use for 2-3 months is recommended.
Shipping & Returns
Shipping & Returns
We offer fast, tracked worldwide shipping to ensure your order arrives safely and reliably.
Orders are shipped 1-2 business days after they're placed. Delivery takes 3-7 days depending on where the order is going.
Every purchase is backed by our 90-day money-back guarantee. If you’re not satisfied with your experience, simply contact us for support.
Real Stories, Real Results
Honest experiences from our lovely customers
"A month before I found Mazara, I was looking into buying a motorized wheelchair. Now I'm walking my dog again. My nerves actually feel like they're healing."
Eric S.
"This has genuinely changed my life for the better. I'm pain free and I can play with my grandchildren again!"
Victoria A.
"The tingling is 70% better and I have my mind back. No brain fog. No weight gain. I'm 68 now and have more energy than I did in my early 60s."
Monique C.
"My neurologist asked what I changed! No more gabapentin fog. My wife says I'm 'back to myself.' This actually works better than my prescription did, and I can think clearly again."
John W.
"Within 6 weeks, my systolic burning sensation dropped significantly. My neurologist asked what I changed!"
Lizzy A.
"A month before I found Mazara, I was looking into buying a motorized wheelchair. Now I'm walking my dog again. My nerves actually feel like they're healing."
Eric S.
"This has genuinely changed my life for the better. I'm pain free and I can play with my grandchildren again!"
Victoria A.
"The tingling is 70% better and I have my mind back. No brain fog. No weight gain. I'm 68 now and have more energy than I did in my early 60s."
Monique C.
"My neurologist asked what I changed! No more gabapentin fog. My wife says I'm 'back to myself.' This actually works better than my prescription did, and I can think clearly again."
John W.
"Within 6 weeks, my systolic burning sensation dropped significantly. My neurologist asked what I changed!"
Lizzy A.
The Research
Major Clinical Studies on Alpha-Lipoic Acid
Alpha-lipoic acid is one of the most heavily studied compounds in nerve health — with published trials running from three weeks to four years. Here's what the research actually found.
- The longest randomized placebo-controlled trial ever run in diabetic nerve disease — four years, 36 centers across the US, Canada, and Europe.
- Participants took 600 mg orally, once a day — the same dose and route as a daily softgel.
- Significantly more people on alpha-lipoic acid showed clinically meaningful improvement, and significantly fewer got worse, on both the Neuropathy Impairment Score (p = 0.013) and its lower-limb version (p = 0.025).
- Impairment scores improved against placebo across the board: NIS (p = 0.028), NIS-LL (p = 0.05), and muscular weakness (p = 0.045).
- Well tolerated over four straight years — tolerability ratings and dropouts were no different from placebo.
- Note: the trial's primary composite endpoint did not separate from placebo (p = 0.105); the benefits above were secondary and response-analysis findings. Serious adverse events were higher on ALA (38.1%) than placebo (28.0%).
- Total Symptom Score improved by an average of 5.7 points on alpha-lipoic acid versus 1.8 points on placebo — a highly significant difference (p < 0.001).
- Every single symptom measured improved significantly against placebo: burning pain, lancinating pain, prickling, and asleep numbness.
- Improvement showed up fast — within the 3-week treatment window.
- Neuropathy Impairment Score and a nerve conduction measure also improved, alongside patients' own global rating of how well it worked.
- Researchers attributed the relief to improved nerve pathophysiology — not to better blood sugar control.
- Note: this trial delivered 600 mg of racemic alpha-lipoic acid intravenously, not orally.
- The trial that showed swallowing it works — not just IV. Participants took oral alpha-lipoic acid for three weeks.
- Total Symptom Score in the feet dropped by 3.75 points versus placebo (p = 0.021).
- The burning component of the score improved significantly on its own (p = 0.012).
- Neuropathy Disability Score — an objective clinical measure, not a self-report — also improved significantly (p = 0.025).
- No specific side effects were reported, and adverse events were no different from placebo.
- Note: small single-center study using 600 mg three times daily (1,800 mg/day) of racemic alpha-lipoic acid.
- The rare study using the pure R-(+) form specifically — the same enantiomer in this formula.
- Patients reported a 40% reduction in lower-limb pain and a 35% improvement in general wellness by day 30.
- Nerve conduction velocity measurably increased: +22% motor in the SPE nerve, +16% ulnar, +22% sensory in the sural nerve.
- Oxidative stress markers moved in every direction you'd want: ROS production rate down 16%, lipid damage (TBARS) down 31%, protein damage (carbonyls) down 38%, total antioxidant capacity up 48%.
- All changes reached statistical significance (p < 0.05) by 30–60 days, and no participant dropped out over the full 120 days.
- Note: small preliminary study with no placebo group, using 1.6 g daily.
Research summaries are provided for informational purposes only. These studies were conducted on alpha-lipoic acid as a compound and were not conducted on this product. Doses, formulations, and routes of administration varied between trials and may differ from this product. This product is not intended to diagnose, treat, cure, or prevent any disease.
4 Clinically Studied Benefits of R-Alpha Lipoic Acid
Pure R-Form Only
Pure R-(+)-Alpha Lipoic Acid—the biologically active form your body recognizes—delivering 2× the bioavailability of racemic ALA for maximum nerve cell support.
600mg Clinical Dose
Precisely formulated at 600mg per serving—the exact dosage used in German ALADIN, SYDNEY, and NATHAN clinical trials spanning 4,000+ patients.
Mitochondrial Support
Designed to cross the blood-nerve barrier and penetrate mitochondria, addressing oxidative stress at the source—not just masking pain signals.
Clean & Tested Quality
Every batch is third-party lab tested for purity and potency to meet clean supplement standards—no S-isomer blockers.
94%
Noticed better sleep quality than typical nerve medications
88%
Said they would continue using Mazara daily
91%
Said they were satisfied with the product quality
89%
Said they noticed support for healthy mobility
Proven Benefits. Backed by Science.
Your body deserves more than empty claims. Mazara® R-Alpha Lipoic Acid supports key areas of nerve health using ingredients studied in clinical research.
Nerve Function Support
Supports healthy nerve signaling*
R-Alpha Lipoic Acid crosses the blood-nerve barrier to support healthy nerve function and mitochondrial energy production in peripheral nerve cells as part of a healthy lifestyle.*
Mitochondrial Antioxidant
Supports cellular energy production*
Naturally rich in antioxidant properties, R-ALA helps support mitochondrial health and cellular resilience against oxidative stress when used consistently as part of a healthy lifestyle.*
Pure R-Form Formula
No S-isomer blockers, maximum bioavailability*
Our formula contains only pure R-(+)-Alpha Lipoic Acid—the biologically active form your body recognizes—formulated with coconut oil for enhanced absorption, making this gentle and suitable for daily use without digestive discomfort.*
Clinical Dose & Safety
600mg per serving, backed by research*
By supporting cellular health and antioxidant balance, R-Alpha Lipoic Acid at 600mg—the exact dose used in German clinical trials—fits naturally into daily routines focused on long-term nerve and metabolic wellness.*
What to expect
-
WEEKS 1-2
Easy Start
✓ Simple daily routine with three softgels
✓ No gabapentin-like side effects: no brain fog, no weight gain
✓ Gentle on the stomach with coconut oil for absorption
✓ Feeling comfortable staying consistent -
WEEK 3-4
Cellular Support Begins
✓ R-ALA crosses blood-nerve barrier/reaches mitochondria
✓ Many report initial improvements in sleep quality
✓ Daily routine feels natural and sustainable
✓ Mitochondrial support becomes part of your routine -
WEEK 5-8
Nerve Function & Comfort
✓ Supporting healthy nerve signaling and cellular functioning
✓ Greater comfort in feet and legs reported by many users
✓ Customers begin noticing quality of life improvements
✓ Continued ease of daily use without withdrawal concerns -
WEEK 8+
Long-Term Nerve Health
✓ Ongoing nerve function and mitochondrial wellness support
✓ Cellular resilience through antioxidant protection
✓ Consistent daily habit designed for long-term use
✓ A routine built around addressing root causes, not masking symptoms
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